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Multiple Choice
Where in a eukaryotic cell does the Krebs (citric acid) cycle primarily occur?
A
Mitochondrial matrix
B
Rough endoplasmic reticulum lumen
C
Mitochondrial intermembrane space
D
Cytosol
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Verified step by step guidance
1
Recall that the Krebs cycle, also known as the citric acid cycle, is a key metabolic pathway involved in cellular respiration, where acetyl-CoA is oxidized to produce energy-rich molecules like NADH and FADH2.
Understand that in eukaryotic cells, cellular respiration is compartmentalized, with different stages occurring in specific locations within the cell.
Identify that the Krebs cycle takes place inside the mitochondria, but more specifically, it occurs in the mitochondrial matrix, which is the innermost compartment enclosed by the inner mitochondrial membrane.
Note that the rough endoplasmic reticulum lumen is involved in protein synthesis and folding, not in the Krebs cycle.
Recognize that the mitochondrial intermembrane space is the area between the inner and outer mitochondrial membranes, important for the electron transport chain but not the Krebs cycle, and the cytosol is where glycolysis occurs, not the Krebs cycle.