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Multiple Choice
Which of the following does NOT occur during mitosis?
A
Alignment of chromosomes at the metaphase plate followed by separation of sister chromatids
B
Replication of DNA to produce sister chromatids
C
Condensation of chromosomes and breakdown of the nuclear envelope
D
Re-formation of the nuclear envelope around separated chromosome sets
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Verified step by step guidance
1
Step 1: Understand the phases of mitosis and what key events occur in each phase. Mitosis consists of prophase, metaphase, anaphase, and telophase, followed by cytokinesis.
Step 2: Recall that DNA replication occurs during the S phase of interphase, which is before mitosis begins. Therefore, DNA replication is not part of mitosis itself.
Step 3: Identify the events that do occur during mitosis: chromosomes condense and the nuclear envelope breaks down during prophase; chromosomes align at the metaphase plate during metaphase; sister chromatids separate during anaphase; and the nuclear envelope re-forms during telophase.
Step 4: Compare the given options to these events. The option stating 'Replication of DNA to produce sister chromatids' does not occur during mitosis but rather before mitosis in interphase.
Step 5: Conclude that the correct answer is the event that does NOT occur during mitosis, which is DNA replication.