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22. Organic Chemistry
Chirality
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Predict enantiomer for thalidomide compound given below.
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Verified step by step guidance1
Identify the chiral center in the thalidomide molecule. A chiral center is a carbon atom that is bonded to four different groups.
Assign priorities to the four groups attached to the chiral center based on the Cahn-Ingold-Prelog priority rules. The group with the highest atomic number gets the highest priority.
Orient the molecule so that the group with the lowest priority (usually hydrogen) is pointing away from you.
Determine the order of the remaining three groups. If the order is clockwise, the configuration is R (rectus). If the order is counterclockwise, the configuration is S (sinister).
Compare the configurations of the two enantiomers. The enantiomer with the opposite configuration at the chiral center is the one you are predicting.
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