Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Assuming that Migaloo's albinism is caused by a rare recessive gene, what would be the likelihood of the establishment of a natural robust subpopulation of albino white humpback whales in this population?

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. What data would be helpful in determining the answer to part (a)?

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Do you think that Migaloo's albinism is more likely caused by a dominant or recessive mutation? Explain your reasoning.

A male and a female are each heterozygous for both cystic fibrosis (CF) and phenylketonuria (PKU). Both conditions are autosomal recessive, and they assort independently.

What proportion of the children of this couple will have neither condition?

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Assuming that Migaloo's albinism is caused by a rare dominant gene, what would be the likelihood of the establishment of a natural robust subpopulation of albino white humpback whales in this population?

A woman expressing a dominant phenotype is heterozygous (Dd) for the gene.

Draw a pedigree that illustrates the transmission of the dominant trait from the grandmother to two of her grandchildren who are first cousins.

A woman expressing a dominant phenotype is heterozygous (Dd) for the gene.

What is the probability that two grandchildren of the woman who are first cousins to one another will each inherit the dominant allele?

Two parents who are each known to be carriers of an autosomal recessive allele have four children. None of the children has the recessive condition. What is the probability that one or more of the children is a carrier of the recessive allele?

A man and a woman are each heterozygous carriers of an autosomal recessive mutation of a disorder that is fatal in infancy. They both want to have multiple children, but they are concerned about the risk of the disorder appearing in one or more of their children. In separate calculations, determine the probabilities of the couple having five children with 0, 1, 2, 3, 4, and all 5 children being affected by the disorder.