Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

3. Extensions to Mendelian Inheritance

Overview of interacting Genes

Genetics

3. Extensions to Mendelian Inheritance

Overview of interacting Genes

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Multiple Choice

Which of the following is a method scientists use to overcome the limitations of DNA microarray technology when studying gene interactions?

Reducing the hybridization time to minimize background noise

Increasing the number of fluorescent dyes used in microarrays

Relying solely on single-gene knockout experiments

Utilizing RNA sequencing (RNA-seq) for higher sensitivity and broader dynamic range

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Verified step by step guidance

Understand the limitation of DNA microarray technology: it has a limited dynamic range and sensitivity, which can affect the detection of low-abundance transcripts and subtle gene expression changes.

Recognize that DNA microarrays rely on hybridization of fluorescently labeled cDNA to probes on a chip, which can introduce background noise and limit the number of genes analyzed simultaneously.

Consider alternative methods that provide higher sensitivity and a broader dynamic range, such as RNA sequencing (RNA-seq), which sequences cDNA fragments directly and quantifies gene expression more accurately.

Evaluate why other options are less effective: reducing hybridization time may reduce background noise but does not address sensitivity; increasing fluorescent dyes is limited by spectral overlap; single-gene knockouts do not capture complex gene interactions.

Conclude that utilizing RNA-seq is a method scientists use to overcome microarray limitations because it allows for more comprehensive and precise analysis of gene expression and interactions.