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Multiple Choice
For the eukaryotic DNA sequence shown below, which of the following correctly describes the directionality of the two strands in a double helix?
A
The two strands have random orientation with respect to each other.
B
Both strands run parallel to each other, oriented 5' to 3'.
C
Both strands run parallel to each other, oriented 3' to 5'.
D
The two strands run antiparallel to each other, with one strand oriented 5' to 3' and the other 3' to 5'.
Verified step by step guidance
1
Recall that DNA strands in a double helix have directionality, meaning each strand has a 5' end and a 3' end based on the carbon numbering in the sugar backbone.
Understand that in a double-stranded DNA molecule, the two strands are complementary and run in opposite directions, a feature known as antiparallel orientation.
Recognize that one strand runs from the 5' end to the 3' end, while the complementary strand runs from the 3' end to the 5' end, allowing proper base pairing and the formation of hydrogen bonds.
Eliminate options that suggest random orientation or parallel strands running in the same direction, as these do not support the stable structure of the DNA double helix.
Conclude that the correct description is that the two strands run antiparallel to each other, with one strand oriented 5' to 3' and the other 3' to 5'.