Multiple Choice
Which of the following best describes the function of the golup gene in organisms where it is active?
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3. Extensions to Mendelian Inheritance
Overview of interacting Genes
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What is the outcome when pluripotency factors stimulate the expression of Tsix in early embryonic development?
A
Pluripotency factors cause both X chromosomes to be inactivated.
B
Tsix expression leads to the activation of Y-linked genes.
C
Xist expression is repressed, preventing X chromosome inactivation.
D
Xist expression is increased, leading to X chromosome inactivation.
Verified step by step guidance1
Understand the role of pluripotency factors in early embryonic development: these factors maintain the cells in a pluripotent state and regulate gene expression related to X chromosome inactivation.
Recognize that Tsix is an antisense transcript of the Xist gene, and its expression negatively regulates Xist expression.
Recall that Xist is responsible for initiating X chromosome inactivation by coating the X chromosome and silencing it.
Analyze how stimulation of Tsix expression by pluripotency factors leads to repression of Xist, thereby preventing the initiation of X chromosome inactivation.
Conclude that when pluripotency factors stimulate Tsix, Xist expression is repressed, which maintains both X chromosomes in an active state during early embryonic development.
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