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Multiple Choice
Based on the principles of mitochondrial DNA inheritance, which of the following pairs of family members in a pedigree are most likely to share identical mitochondrial DNA?
A
Mother and her children
B
Brother and sister
C
Father and mother
D
Father and his children
Verified step by step guidance
1
Understand that mitochondrial DNA (mtDNA) is inherited exclusively from the mother because mitochondria in the sperm are typically not transmitted to the offspring.
Recognize that all children of a mother will inherit her mitochondrial DNA, making their mtDNA sequences identical or nearly identical to hers.
Note that siblings (brother and sister) share nuclear DNA from both parents but may not have identical mitochondrial DNA unless they share the same mother.
Realize that the father does not pass mitochondrial DNA to his children, so neither father and mother nor father and his children pairs will share identical mtDNA.
Conclude that the pair most likely to share identical mitochondrial DNA is the mother and her children, based on maternal inheritance of mtDNA.