Multiple Choice
In eukaryotic chromosome structure, why do histones bind tightly to DNA?
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7. DNA and Chromosome Structure
Eukaryotic Chromosome Structure
Multiple Choice
In the context of eukaryotic chromosome structure, why does DNA need to be coiled (packaged into chromatin)?
A
To convert DNA into RNA before it can be transcribed
B
To compact DNA so it fits within the nucleus and can be organized into chromosomes
C
To prevent DNA replication from occurring during the S phase of the cell cycle
D
To increase the mutation rate by exposing bases to the nuclear environment
Verified step by step guidance1
Understand the physical scale of DNA: Eukaryotic cells contain a large amount of DNA, which if stretched out, would be much longer than the diameter of the nucleus.
Recognize the need for compaction: To fit this long DNA molecule inside the relatively small nucleus, the DNA must be tightly packed and organized.
Learn about chromatin structure: DNA wraps around histone proteins forming nucleosomes, which further coil and fold to create chromatin, effectively compacting the DNA.
Connect packaging to chromosome formation: This coiling and folding allow DNA to be organized into distinct chromosomes, which are essential for proper segregation during cell division.
Clarify that DNA packaging is not for transcription conversion or mutation increase: Packaging primarily serves spatial organization and protection, not directly converting DNA to RNA or increasing mutation rates.
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