Discuss the similarities and differences between forward and r...

Question

Discuss the similarities and differences between forward and reverse genetic approaches, and when you would choose to utilize each of the approaches.

Accepted Answer

Hello everyone and welcome to today's video. So which of the following statements is true regarding forward and reverse genetic approaches? So let's go over each of these statements and identify the correct one. So forward genetics involves inducing mutation to study the function of known genes or reverse genetics. It starts with a phenotype. This is answer choice. A well, this answer choice is incorrect. But why? Well, the explanation for this is that for genetics involves starting the function of unknown genes. So we don't know the gene that we're studying the function of and that's what we're trying to discover. So this is the incorrect aspect of this answer choice. And because of this, we're going to cancel it out. Moving on, we have reverse genetics require specific knowledge of the gene of enter as well. For genetics involves random mudi genesis. This is also going to be incorrect. But why? Well, reverse genetics typically involves disrupting or manipulating the function of the gene to study its effects on the phenotype. Well, for genetics may involve neogenesis to identify novel genes. But the incorrect aspect here is in this first sentence, reverse genetics require specific knowledge of the gene of interest. We really don't know the gene that we're going for here. We're actually trying to study its functions to determine its effect on the phenotype. And because of this, we're also going to cancel it out. Then we have see both forward and reverse genetics involves mapping and sequencing of mutated genes that is also going to be incorrect. But why? Well, mapping and sequencing of mutated genes are actually only going to be involved with forward genetics. Remember that reverse genetics, we have a gene of interest that is usually known and it's going to be manipulated directly. Therefore, this is also incorrect. We're going to cancel it out. And finally, we have the forward genetics is used to study novel genes while reverse genetic focuses on identifying gene phenotype relationship, this is going to be correct because forward genetics is used to study and identify novel genes because we're inducing mutations and observing the resulting phenotypes. While reverse genetics focuses on studying the relationship between this knownn gene and their phenotypic effect by disrupting or manipulating the function of the gene of interest. So this is a correct answer choice and we're going to highlight it as the final answer to our question. So, D for genetics is used to study novel genes or reverse genetics, focuses on identifying gene phenotype relationships. I really hope this helped and I hope to see you on the next video

Discuss the similarities and differences between forward and reverse genetic approaches, and when you would choose to utilize each of the approaches.

Key Concepts

Forward Genetics

Reverse Genetics

Choosing Between Approaches

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