Define and distinguish epistasis and pleiotropy.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Epistasis and Complementation
Problem 18b
Textbook Question
Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

What are the possible genotype(s) for true-breeding blue petunias?

1
Understand the problem: The question asks for the possible genotype(s) of true-breeding blue petunias. From the diagram, we see that blue pigment is produced by Pathway I, which is controlled by gene A. Pathway II, controlled by gene B, is responsible for red pigment. True-breeding means the genotype must be homozygous for the trait in question.
Analyze Pathway I: For a petunia to produce blue pigment, gene A must be functional. This means the genotype for gene A must be homozygous dominant (AA) to ensure consistent production of the enzyme required to convert the colorless pigment to blue.
Analyze Pathway II: To ensure the petunia is blue and not purple, it must not produce red pigment. This means gene B must be non-functional. A non-functional gene B is represented by the homozygous recessive genotype (bb), which prevents the conversion of the colorless pigment to red.
Combine the genotypes: Since the petunia must be true-breeding for blue, the genotype must be homozygous for both traits. This results in the genotype AA for gene A (blue pigment production) and bb for gene B (no red pigment production).
Conclude the solution: The possible genotype(s) for true-breeding blue petunias is AA bb. This ensures that the petunia consistently produces blue pigment and no red pigment, resulting in a blue flower color.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Gene Action and Enzymatic Pathways
Gene action refers to the process by which genes produce enzymes that catalyze biochemical reactions. In the case of petunias, two distinct pathways are involved in pigment synthesis: Pathway I, where gene A converts a colorless pigment to blue, and Pathway II, where gene B converts a colorless pigment to red. Understanding these pathways is crucial for determining how different flower colors are produced.
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Independent Assortment
Independent assortment is a fundamental principle of genetics stating that alleles for different genes segregate independently during gamete formation. In this scenario, the genes controlling blue and red pigment synthesis (genes A and B) assort independently, meaning the inheritance of one does not affect the inheritance of the other. This principle is essential for predicting the genotypes of offspring based on parental traits.
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True-Breeding Genotypes
True-breeding organisms are homozygous for a particular trait, meaning they carry two identical alleles. For blue petunias, which are produced by the action of gene A, the true-breeding genotype would be homozygous for the allele that produces blue pigment. This understanding is vital for identifying the possible genotypes of true-breeding blue petunias, which would be represented as 'AA' if 'A' is the dominant allele responsible for blue pigment synthesis.
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