Multiple Choice
Areas with higher bicoid expression will develop into which body pattern?
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14. Genetic Control of Development
Developmental Patterning Genes
0:28 minutesProblem 1e
Textbook Question
In the discussion, we have focused on large-scale as well as the inter- and intracellular events that take place during embryogenesis and the formation of adult structures. In particular, we discussed how the adult body plan is laid down by a cascade of gene expression, and the role of cell–cell communication in development. Based on your knowledge of these topics, answer several fundamental questions:
How do we know that eye formation in all animals is controlled by a binary switch gene?
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Understand the concept of a binary switch gene: A binary switch gene is a master regulatory gene that controls the development of a specific structure or organ. It acts as a 'switch' to initiate the developmental program for that structure.
Review the evidence supporting the role of binary switch genes in eye formation: Research has shown that the Pax6 gene is conserved across many species and is essential for eye development. Mutations in Pax6 lead to defects in eye formation, demonstrating its critical role.
Examine cross-species studies: Experiments have shown that introducing Pax6 from one species into another can still induce eye formation, indicating that the gene's function is conserved and acts as a binary switch for eye development.
Consider the role of gene expression cascades: Pax6 activates downstream genes involved in eye development, creating a cascade of gene expression that leads to the formation of the eye structure. This supports the idea of Pax6 as a master regulator.
Analyze cell–cell communication in development: During embryogenesis, Pax6 interacts with signaling pathways and other genes to coordinate the development of the eye. This highlights the importance of both genetic and cellular interactions in the process.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Binary Switch Genes
Binary switch genes are regulatory genes that control the expression of other genes in a developmental pathway, often determining the presence or absence of specific structures. In the context of eye formation, these genes can toggle between two states, leading to the activation of a cascade of downstream genes that promote eye development. This concept is crucial for understanding how a single genetic switch can influence complex developmental processes across different species.
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Conservation of Developmental Pathways
The conservation of developmental pathways refers to the phenomenon where similar genetic mechanisms are preserved across diverse species throughout evolution. This suggests that fundamental processes, such as eye formation, are regulated by analogous genes in different organisms. Studying these conserved pathways helps scientists understand the evolutionary relationships and functional similarities in developmental biology.
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Cell-Cell Communication in Development
Cell-cell communication is essential during embryogenesis, as it allows cells to coordinate their activities and respond to signals from neighboring cells. This interaction is crucial for the proper formation of tissues and organs, including the eyes. Understanding how cells communicate and influence each other's fate is key to deciphering the complex processes that lead to the establishment of the body plan and organogenesis.
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