Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Epistasis and Complementation
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Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Two heterozygous organisms are crossed, and the F2 phenotypic ratio is 12:3:1. What form of epistasis do these two genes exhibit?
A
Dominant Epistasis
B
Recessive Epistasis
C
Suppressors
D
Complementary Gene Action

1
Understand the concept of epistasis: Epistasis occurs when the effect of one gene is dependent on the presence of one or more 'modifier genes'. In this context, we are looking at how two genes interact to affect a phenotype.
Identify the phenotypic ratio: The given F2 phenotypic ratio is 12:3:1. This ratio is a key indicator of the type of epistasis at play.
Recall the typical phenotypic ratios associated with different types of epistasis: Dominant epistasis often results in a 12:3:1 ratio, where one dominant allele masks the effects of another gene.
Compare the given ratio with known epistatic ratios: The 12:3:1 ratio is characteristic of dominant epistasis, where the presence of a dominant allele in one gene masks the expression of alleles at a second gene.
Conclude the type of epistasis: Based on the comparison, the form of epistasis exhibited by these two genes is dominant epistasis, as the 12:3:1 ratio matches the expected outcome for this type of genetic interaction.
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Related Practice
Multiple Choice
Which statement below defines epistasis?
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Epistasis and Complementation practice set
