Outline the events that occur during initiation of translation in E. coli.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
11. Translation
Translation
Problem 7
Textbook Question
Assuming that each nucleotide in an mRNA is 0.34 nm long, how many triplet codes can simultaneously occupy the space in a ribosome that is 20 nm in diameter?

1
Understand the problem: We need to find how many triplet codons (each consisting of 3 nucleotides) can fit within the length of the ribosome, which is given as 20 nm in diameter.
Calculate the total number of nucleotides that can fit in the 20 nm space by dividing the ribosome diameter by the length of one nucleotide: .
Determine how many triplet codons fit by dividing the total number of nucleotides by 3, since each codon consists of 3 nucleotides: .
Interpret the result as the number of triplet codes that can simultaneously occupy the ribosome space.
Remember that the ribosome diameter is a linear measurement, so this calculation assumes the codons are arranged linearly along the length of the ribosome.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
mRNA Structure and Nucleotide Length
mRNA is a single-stranded molecule composed of nucleotides, each approximately 0.34 nm in length. Understanding this length is essential to calculate how many nucleotides can fit within a given physical space, such as the ribosome.
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DNA Structure
Triplet Codon Concept
A triplet codon consists of three consecutive nucleotides on mRNA that encode a specific amino acid during protein synthesis. Knowing that codons are groups of three nucleotides helps determine how many codons fit into a segment of mRNA.
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The Genetic Code
Ribosome Size and mRNA Accommodation
The ribosome is a molecular machine where translation occurs, with a defined physical size (20 nm diameter here). Understanding the ribosome's spatial constraints allows calculation of how many codons can simultaneously occupy its mRNA-binding site.
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Ribosome Structure
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