Describe and give an example (real or hypothetical) of each of...

Question

Describe and give an example (real or hypothetical) of each of the following:

Silencer sequence action

Accepted Answer

Hi, everybody. Here's our next question. It says which of the following is a silencer element that regulates gene expression during development. Choice. A neuronal restrictive silencing element N R E choice B upstream repressor element U R E choice C test a specific element T S E or choice D A U rich element A R E. So we're looking for a silencer element. So something that silences gene expression during development and of course, things like silencing is very important during development because timing is everything you have genes that are expressed at very specific times and need to be turned on and turned off with great precision. So silencing is important. Otherwise, you have uncontrolled cell division and growth. Well, if I couldn't remember off the top of my head, I've got only one answer. Choice that has the term silencing element in it. And that's choice. A, the neuronal restrictive silencing element. So that's gonna lead me to choice A or that's going to lead me to choice A, even if I don't recall anything about any of these. And that is our correct answer. It's involved in silencing gene transcription. So it's a silencer during neuronal development and it works by binding to transcription factors and chromatin modifying enzymes preventing them from binding to regulatory elements like enhancers that prevent them from activating gene expression. Let's just look briefly at our other answer choices to understand why they are not correct the upstream repressor element. Um even though we have the word repressor in there, so that might tempt us a little bit is a regulatory element in gene expression of yeast cells. So not involved in development where we're talking about higher U Caros. So that's why that's not correct to see. The test is specific, specific element is involved in the regulation of gene expression but only in the testes. So not in the wider um types of cells during development overall. So not as good an answer as choice. A and then to the A U rich element is involved in the regulation of M R N A, the ability and degradation, but not in development. So that's why that's not our correct answer. So we've got a lot of regulatory elements here, but we're specifically looking for a silencer element that regulates gene expression during development. And that would be choice. A neuronal restrictive silencing element or N R E. See you in the next video.

Describe and give an example (real or hypothetical) of each of the following:
Silencer sequence action

Key Concepts

Silencer Sequences

Transcription Regulation

Example of Silencer Action

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