Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

19. Cancer Genetics

Overview of Cancer

Genetics

19. Cancer Genetics

Overview of Cancer

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Problem C.11b

Textbook Question

Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. What genes are most commonly mutated in Lynch syndrome?

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Understand that Lynch syndrome is a hereditary condition associated with a higher risk of certain types of cancer, particularly colorectal cancer, caused by mutations in specific genes involved in DNA mismatch repair.

Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the search box to access detailed genetic information about the syndrome.

From the search results, select the entry labeled '#120435—Lynch Syndrome' to view the curated genetic data related to this condition.

Review the gene section in the entry, which lists the genes most commonly mutated in Lynch syndrome. These genes typically include those involved in the DNA mismatch repair pathway.

Note the names of the key genes, such as MLH1, MSH2, MSH6, and PMS2, which are frequently reported as mutated in individuals with Lynch syndrome.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Lynch Syndrome

Lynch syndrome is an inherited disorder that increases the risk of colorectal cancer and other cancers. It is caused by mutations in genes responsible for DNA mismatch repair, leading to genetic instability. Understanding this syndrome helps in identifying at-risk individuals and guiding genetic testing.

DNA Mismatch Repair Genes

DNA mismatch repair (MMR) genes encode proteins that correct errors during DNA replication. Mutations in these genes impair repair mechanisms, causing accumulation of mutations and cancer development. Key MMR genes include MLH1, MSH2, MSH6, and PMS2, which are commonly mutated in Lynch syndrome.

Genetic Mutation and Cancer Risk

Mutations in specific genes can disrupt normal cellular functions and increase cancer susceptibility. In Lynch syndrome, inherited mutations in MMR genes lead to microsatellite instability and tumor formation. Recognizing these mutations is crucial for diagnosis, risk assessment, and preventive strategies.

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Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. What are the approximate rates of cancer that develop in people carrying a mutation of one of these genes?

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Textbook Question

Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. Provide a brief summary of the normal functions of the protein products of these genes.

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Textbook Question

Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. There are two types of Lynch syndrome. What are they?

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