Consider the following pedigree.

Predict the mode of inheritance of the trait of interest and the most probable genotype of each individual. Assume that the alleles A and a control the expression.

Researchers examined a family with an interesting distribution of Leigh syndrome symptoms. In this disorder, individuals may show a progressive loss of motor function (ataxia, A) with peripheral neuropathy (PN, meaning impairment of the peripheral nerves). A mitochondrial DNA (mtDNA) mutation that reduces ATPase activity was identified in various tissues of affected individuals. The accompanying table summarizes the presence of symptoms in an extended family.

Develop a pedigree that summarizes the information presented in the table.

For each pedigree shown,

Identify which pattern(s) of transmission is/are impossible. Specify why transmission is impossible.

For each pedigree shown,

Determine which other pattern(s) of transmission is/are possible. For each possible mode of transmission, specify the genotypes necessary for transmission to occur.

Use the blank pedigrees provided to depict transmission of

(a) an X-linked recessive trait and

(b) an X-linked dominant trait, by filling in circles and squares to represent individuals with the trait of interest. Give genotypes for each person in each pedigree.

Carefully design each transmission pattern so that pedigree

(a) cannot be confused with autosomal recessive transmission and pedigree

(b) cannot be confused with autosomal dominant transmission. Identify the transmission events that eliminate the possibility of autosomal transmission for each pedigree.

The accompanying pedigree shows the transmission of a phenotypic character. Using B to represent a dominant allele and b to represent a recessive allele,

Give the genotype(s) possible for each member of the family, assuming the trait is autosomal recessive. 

The accompanying pedigree shows the transmission of a phenotypic character. Using B to represent a dominant allele and b to represent a recessive allele,

Give the genotype(s) possible for each member of the family, assuming the trait is autosomal dominant. 

Draw all possible conclusions concerning the mode of inheritance of the trait portrayed in the following limited pedigree.

Draw all possible conclusions concerning the mode of inheritance of the trait portrayed in the following limited pedigree.