Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

2. Mendel's Laws of Inheritance

Mendel's Experiments and Laws

Genetics

2. Mendel's Laws of Inheritance

Mendel's Experiments and Laws

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1:20 minutes

Problem 50a

Textbook Question

Select a human hereditary disease or condition you would like to know more about. Using the OMIM website (http://www.ncbi.nlm.nih.gov/omim), search for the disease and prepare a short synopsis of your findings. Include the following information:
The gene mutated in the disease and its chromosome location.

Verified step by step guidance

Visit the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and use the search bar to look up the hereditary disease or condition you are interested in.

Identify the specific entry for the disease in the search results and click on it to access detailed information.

Locate the section that describes the gene(s) associated with the disease. Note the name of the gene and its function.

Find the chromosome location of the gene. This information is typically provided in the format 'chromosome number: position' or 'cytogenetic band'.

Summarize your findings, including the name of the gene, its chromosome location, and any relevant details about how the mutation leads to the disease.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Genetic Mutations

Genetic mutations are alterations in the DNA sequence that can lead to changes in gene function. These mutations can be inherited or occur spontaneously and can result in various hereditary diseases. Understanding the type of mutation (e.g., point mutation, deletion, insertion) is crucial for identifying how it affects the gene and contributes to the disease phenotype.

Chromosomal Location

The chromosomal location of a gene refers to its specific position on a chromosome, which is essential for understanding its role in genetic disorders. Each gene is mapped to a particular locus, and knowing this location helps in studying gene interactions, inheritance patterns, and the impact of mutations on the organism. This information is often represented in a format like 'chromosome number: position'.

Online Mendelian Inheritance in Man (OMIM)

OMIM is a comprehensive, authoritative database that catalogs human genes and genetic disorders. It provides detailed information about the genetic basis of diseases, including gene mutations, chromosomal locations, and clinical features. Utilizing OMIM is crucial for researching specific hereditary conditions, as it offers insights into the genetic mechanisms underlying these diseases.

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Related Practice

Textbook Question

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the Search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:

Briefly describe the disease.

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Textbook Question

Go to the OMIM website (http://www.ncbi.nlm.nih.gov/omim) and locate the Search button at the top of the page. Use the search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: 'Tay–Sachs disease' (select OMIM number 272800 from the search results list); 'cystic fibrosis' (select OMIM number 602421 from the search results list); and 'sickle cell anemia' (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:

What gene is mutated in the disease?

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Textbook Question

On which chromosome is the gene for the disease located?

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Textbook Question

Select a human hereditary disease or condition you would like to know more about. Using the OMIM website (http://www.ncbi.nlm.nih.gov/omim), search for the disease and prepare a short synopsis of your findings. Include the following information:

A description of the disease or condition.

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Multiple Choice

Which observation made by Mendel refuted the idea of blending inheritance?

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Multiple Choice

In Mendel's experiments, a cross between an aabb individual and another aabb individual will produce offspring with which genotype?

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Multiple Choice

What was Mendel's most significant conclusion from his research with pea plants?

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