What is apoptosis, and under what circumstances do cells undergo this process?

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Understand that apoptosis is a form of programmed cell death, a controlled process by which cells orderly dismantle themselves without causing harm to the surrounding tissue.

Recognize that apoptosis is different from necrosis, which is uncontrolled cell death due to injury or damage.

Identify the key circumstances under which cells undergo apoptosis, such as during normal development (e.g., shaping organs), eliminating damaged or infected cells, and maintaining tissue homeostasis.

Note that apoptosis can be triggered by internal signals like DNA damage or external signals such as binding of death ligands to cell surface receptors.

Summarize that apoptosis is essential for organismal health by removing unwanted or potentially harmful cells in a regulated manner.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Apoptosis

Apoptosis is a programmed cell death process that allows cells to die in a controlled and regulated manner. It is essential for maintaining tissue homeostasis and eliminating damaged or unnecessary cells without causing inflammation.

Triggers of Apoptosis

Cells undergo apoptosis in response to various internal and external signals, such as DNA damage, oxidative stress, infection, or developmental cues. These triggers activate signaling pathways that initiate the apoptotic process.

Mechanisms of Apoptosis

Apoptosis involves a series of molecular events including activation of caspases, mitochondrial membrane permeabilization, and DNA fragmentation. These mechanisms ensure the cell is dismantled efficiently and safely.

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