Describe how nondisjunction in human female gametes can give rise to Klinefelter and Turner syndrome offspring following fertilization by a normal male gamete.

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Hi everyone, Welcome back. Let's look at our next question. It says a healthy married couple age, 38 years old, consulted a physician about having a baby. They wanted to know if there are any genetic diseases that can arise from conceiving a child at their age, which among the following diseases can manifest in their planned child. Well, there are certain disorders that are more likely when you have advanced maternal age as there's more likely to be errors in the cell division process, causing some of the chromosomes to assort improperly. So let's look at our answer choices here. Keeping in mind the choice E. Is all of the above. So choice A is Klinefelter syndrome. Klinefelter syndrome is when a male is born with X. X. Y. As a genotype. So, an extra X chromosome. Um, this is uh, the incidence of this is higher in females of advanced maternal age. So this is a possibility Choice B is trisomy otherwise known as Down syndrome. So an extra chromosome 21 and this is well known to be of increased risk with advanced maternal age. Do I see his Edwards syndrome and this is true 18? Um, it's it's a very severe uh syndrome, usually lethal shortly after birth or at a very young age. Um, also again because it's a trisomy, an era of division of the chromosomes more likely with advanced maternal age. And finally, choice the potatoes syndrome, which is trisomy 13. Again, anytime you have a trisomy, that risk goes up with advanced maternal age? So our correct answer here is choice E all of the above. So which of these diseases can manifest in a couple who are 38 years old, hoping to conceive any of these disorders, since they all arise in errors of division of chromosomes, which are more likely with advanced maternal age. See you in the next video.

Describe how nondisjunction in human female gametes can give rise to Klinefelter and Turner syndrome offspring following fertilization by a normal male gamete.

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Key Concepts

Nondisjunction

Klinefelter Syndrome

Turner Syndrome