Some proteins are composed of two or more polypeptides. Suppose the DNA template strand sequence 3′-TACGTAGGCTAACGGAGTAAGCTAACT-5′ produces a polypeptide that joins in pairs to form a functional protein.
What term is used to identify a functional protein like this one formed when two identical polypeptides join together?

Answer the following questions for autosomal conditions such as PKU.

If both parents are heterozygous carriers of a mutant allele, what is the chance that their first child will be homozygous recessive for the mutation?

Answer the following questions for autosomal conditions such as PKU.

If the first child of parents who are both heterozygous carriers of a recessive mutant allele is homozygous recessive, what is the chance the second child of the couple will be homozygous recessive? What is the chance the second child will be a heterozygous carrier of the recessive mutation?

Some proteins are composed of two or more polypeptides. Suppose the DNA template strand sequence 3′-TACGTAGGCTAACGGAGTAAGCTAACT-5′ produces a polypeptide that joins in pairs to form a functional protein. What is the amino acid sequence of the polypeptide produced from this sequence?

Homocystinuria is a rare autosomal recessive condition on the RUSP list of conditions screened by newborn genetic testing. The condition results from a mutation that blocks the degradation of the amino acid methionine. The absence of a critical enzyme causes the buildup of the compound homocysteine, which is one of the intermediate compounds in the methionine breakdown pathway. Homocystinuria causes mental impairment, heart problems, seizures, eye abnormalities, and a number of other symptoms that shorten life if not treated. The condition is treated by a specialized diet that is low in methionine and by the ingestion of several supplements.

Why do you think eating a low-methionine diet is critical to controlling homocystinuria?

Homocystinuria is a rare autosomal recessive condition on the RUSP list of conditions screened by newborn genetic testing. The condition results from a mutation that blocks the degradation of the amino acid methionine. The absence of a critical enzyme causes the buildup of the compound homocysteine, which is one of the intermediate compounds in the methionine breakdown pathway. Homocystinuria causes mental impairment, heart problems, seizures, eye abnormalities, and a number of other symptoms that shorten life if not treated. The condition is treated by a specialized diet that is low in methionine and by the ingestion of several supplements.

The low-methionine diet must be maintained throughout life to manage homocystinuria. Why do you think this is the case?

In the experiments that deciphered the genetic code, many different synthetic mRNA sequences were tested.

Describe how the codon for phenylalanine was identified.