A deficiency of the enzyme adenine transferase causes a lack o...

Question

A deficiency of the enzyme adenine transferase causes a lack of adenine for purine synthesis and a high level of adenine in the urine. Draw the condensed structural formula for adenosine monophosphate.

Accepted Answer

All right. Hello everyone. So this question says during a study on nucleotide metabolism, a researcher observes an accumulation of thymidine monophosphate or T MP due to a deficiency in thyme synthese. What is the condensed structural formula for TMP? So before we go ahead and go through the structure of T MP, based on the name, let's recall what a condensed structural formula actually is now a condensed structural formula is basically a way of drawing molecules that's going to show how atoms are connected, but without showing bonds between carbon and hydrogen. So what that means is that all other bonds are going to be drawn, but the bonds between carbon and hydrogen are shown simply as kind of grouping those two atoms together. So for example, if a carbon atom has two hydrogens bound to it, you would simply write CH two and so on. So with that context in mind, what does TMP look like? What are the components of it? Well, first and foremost, based on the first phrase here, thymidine, we already know what one of our components is going to be. Now just to backtrack a little bit more D MP is a nucleotide as mentioned in the text of the question and nucleotides have three main components to them. First is the nitrogen space which given the name we know to be signing. The second component is the sugar backbone in the center of the structure. And the third component is the phosphate group. So when it comes to the sugar backbone of T MP, that's going to be deoxy rivals because recall that thymine is a component found, excuse me is a base found in DNA, which has deoxy rivals as its backbone. As for the phosphate groups, we have only one of them based on the prefix mono and monophosphate. So now we can go ahead and start by drawing out the sugar backbone in the center of the nucleotide. So let's go ahead and do that. Now, as mentioned before, all bonds except those between carbon and hydrogen are going to be shown. So what I'm going to do is draw out the ring as normal, but all of the atoms inside of the ring are going to be shown in the corners. So after that, I'm going to go ahead and group all hydrogens attached to one particular carbon right next to each carbon. But in addition to these atoms inside of the five member ring, recall that both rivals and deoxy rivals have one additional carbon outside of the ring with its own hydroxy group. All right. So in addition to the structural features described here for deoxyribose on carbon. Number one, on the very right side of the structure is another hydroxy group and also attached to the third carbon of the ring. Now, the reason why the sugar is called deoxyribose is because it does not have a hydroxy group on the second carbon of the ring rivals, however, would have the hydroxy group there. Ok. So now let's go ahead and add our nitrogen it space. As mentioned before, the nitrogenous space is fy and thymine is going to go ahead and connect to carbon number one of the deoxy rival sugar. Now, when it connects to the deoxy rival sugar, it's actually going to replace the hydroxy group that was drawn before. So carbon number one would now have a bond between itself and nitrogen. And so from this nitrogen, I'm going to go ahead and draw the remaining atoms of the permed ring because recall that thymine is in fact a perimeter base. So there are going to be two nitrogens inside of this ring. So to the right of the nitrogen connecting to the carbon of deoxy rivals, we have a carbonel group, we have an additional car bono group on the carbon across from our nitrogen here, let me move this down for the sake of space and we also have an additional metal group. So our last step now is to just go ahead and add our final component, which is that phosphate group. Now the phosphate group is going to be associated to carbon number five of deoxy rivals. In other words, the one outside of the ring. So what I'm going to do is erase the hydroxy hydrogen that was previously there. And at a bond between the oxygen attached to carbon five and phosphorus, and then I'm going to add two more single bonds to oxygen with both oxygen atoms having a negative charge and an additional double bond to another oxygen. So as for the structure of T MP here it is. So the one final modification that I'm going to make is just going ahead and shading in these bonds here that are towards the front of the rank structure just to add some dimensionality. But there you have it here is the structure of TNP. And so with that being said, thank you so very much for watching and I hope you found this helpful.

A deficiency of the enzyme adenine transferase causes a lack of adenine for purine synthesis and a high level of adenine in the urine. Draw the condensed structural formula for adenosine monophosphate.

Key Concepts

Adenine and Purine Synthesis

Adenosine Monophosphate (AMP)

Condensed Structural Formula

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