The Meselson-Stahl experiment demonstrated that DNA replication produces new molecules of DNA each containing…

Explore the experimental setup: Meselson and Stahl grew E. coli in a medium containing heavy nitrogen (N-15) and then shifted them to a medium with light nitrogen (N-14). They extracted DNA at various intervals and analyzed it using density gradient centrifugation.

Analyze the results: After one round of replication, the DNA consisted of hybrid molecules, each containing one strand of N-15 DNA and one strand of N-14 DNA. This indicated that DNA replication is semi-conservative.