Multiple Choice
ABC transporters are a part of a superfamily of transporters that have two nucleotide binding domains that bind __________, which is necessary for primary active transport.
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6. Cell Membrane & Transport
ABC Transporters
Multiple Choice
Which of the following best distinguishes P-type transporters from ABC transporters?
A
P-type transporters are found exclusively in prokaryotes, while ABC transporters are found only in eukaryotes.
B
P-type transporters require GTP for energy, whereas ABC transporters require ATP.
C
P-type transporters use ATP hydrolysis to phosphorylate themselves during the transport cycle, whereas ABC transporters use ATP binding and hydrolysis without self-phosphorylation.
D
P-type transporters transport only ions, while ABC transporters transport only sugars.
Verified step by step guidance1
Understand the general function of both transporter types: P-type transporters and ABC transporters are both involved in active transport, moving substances across membranes against their concentration gradients using energy.
Recall the energy source and mechanism for P-type transporters: These transporters use ATP hydrolysis to phosphorylate themselves transiently during the transport cycle, which is a key feature distinguishing them.
Recall the energy source and mechanism for ABC transporters: ABC transporters use ATP binding and hydrolysis to drive transport but do not phosphorylate themselves; instead, ATP binding and hydrolysis induce conformational changes to move substrates.
Compare substrate specificity: P-type transporters typically transport ions (such as H+, Na+, K+, Ca2+), while ABC transporters have a broader range of substrates including sugars, amino acids, and peptides, but this is not the primary distinguishing feature.
Evaluate the given options based on these characteristics to identify the correct distinguishing feature: focus on the unique self-phosphorylation step of P-type transporters versus the ATP-binding and hydrolysis mechanism of ABC transporters without phosphorylation.
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