Multiple Choice
Post-translational control refers to:
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15. Central Dogma & Gene Regulation
Introduction to Regulation of Gene Expression
1:57 minutesProblem 12
Textbook Question
What would the likely consequence be if a gene’s promoter was deleted or severely mutated?
Verified step by step guidance1
Understand the role of a promoter in gene expression: A promoter is a DNA sequence located upstream of a gene that serves as the binding site for RNA polymerase and transcription factors, initiating transcription.
Recognize that if a gene's promoter is deleted or severely mutated, RNA polymerase and associated transcription factors may not be able to bind effectively to the DNA.
Consider that without proper binding of RNA polymerase, the transcription of the gene into messenger RNA (mRNA) will be significantly reduced or completely halted.
Realize that a lack of mRNA production means the gene's encoded protein will not be synthesized, leading to loss of gene function at the protein level.
Conclude that the likely consequence of promoter deletion or severe mutation is a loss or severe reduction of gene expression, which can affect cellular function depending on the gene's role.
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Video duration:
1mKey Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Gene Promoter Function
A gene promoter is a DNA sequence located upstream of a gene that serves as the binding site for RNA polymerase and transcription factors. It is essential for initiating transcription, controlling when and how much a gene is expressed.
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Impact of Promoter Deletion or Mutation
If a promoter is deleted or severely mutated, RNA polymerase cannot effectively bind to the DNA, leading to reduced or completely halted transcription of the gene. This results in little to no production of the gene’s corresponding RNA and protein.
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Gene Expression Regulation
Gene expression is tightly regulated at the transcriptional level, with promoters playing a key role. Changes in promoter sequences can disrupt normal gene regulation, affecting cellular function and potentially causing phenotypic consequences or disease.
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