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Multiple Choice
Which of the following causes transcription to be increased for a specific gene?
A
Histones in that region are deacetylated.
B
DNA is methylated in the regulatory region of the gene.
C
Histones in that region are acetylated.
D
The chromatin structure is tightly packed.
E
B and D.
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Verified step by step guidance
1
Understand the role of histones in gene expression: Histones are proteins that help package DNA into chromatin. Their acetylation status can influence transcription levels.
Learn about histone acetylation: Acetylation of histones typically leads to a more relaxed chromatin structure, allowing transcription machinery better access to DNA, thus increasing transcription.
Explore DNA methylation: Methylation of DNA, especially in regulatory regions, often suppresses gene expression by preventing transcription factors from binding.
Examine chromatin structure: Tightly packed chromatin (heterochromatin) is generally associated with reduced transcription, while loosely packed chromatin (euchromatin) is associated with increased transcription.
Apply this knowledge to the options: Histone acetylation increases transcription, while deacetylation, DNA methylation, and tightly packed chromatin generally decrease transcription.