Match the antimicrobial drug class to its action. You may assign more than one drug class to a given action and some actions may not be applicable.

Why does a cell die from the following antimicrobial actions?

a. Colistimethate binds to phospholipids.

b. Kanamycin binds to 70S ribosomes.

How does each of the following inhibit translation?

a. Chloramphenicol

b. Erythromycin

c. Tetracycline

d. Streptomycin

e. Oxazolidinone

f. Streptogramin

This microorganism is not susceptible to antibiotics or neuromuscular blocks, but is susceptible to protease inhibitors.

Which of the following pairs is mismatched?

a. Antihelminthic—inhibition of oxidative phosphorylation

b. Antihelminthic—inhibition of cell wall synthesis

c. Antifungal—injury to plasma membrane

d. Antifungal—inhibition of mitosis

e. Antiviral—inhibition of DNA synthesis

A patient has an uncomplicated infection with a Gram-negative bacterium. He also has a history of penicillin allergy. Which drug is the best treatment option for this patient?

a. Ampicillin

b. A first-generation cephalosporin

c. A carbapenem

d. Isoniazid

e. Azithromycin

Which drug family would be the most effective to treat a patient diagnosed with a MRSA infection?

a. Penicillins

b. Third-generation cephalosporins

c. Carbapenems

d. Lincosamides

e. Aminoglycosides

Choose the false statement(s). Select all that apply.

a. Antifungal drugs may target cholesterol in fungal cell membranes.

b. Azole and polyene drugs promote cell lysis by impacting fungal cell plasma membranes.

c. Echinocandin drugs inhibit fungal cell wall synthesis.

d. Antifungal drugs may target DNA replication.

e. Antifungal drugs may target protein synthesis.

What advantages might a semisynthetic antimicrobial drug have over an antibiotic?