Textbook Question
Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
_____ ABO blood group antigens are found on nucleated cells.
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Ch. 18 - Immune Disorders
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302
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Table of contents
- Ch. 1 - A Brief History of Microbiology31
- Ch. 2 - The Chemistry of Microbiology28
- Ch. 3 - Cell Structure and Function39
- Ch. 4 - Microscopy, Staining, and Classification25
- Ch. 5 - Microbial Metabolism51
- Ch. 6 - Microbial Nutrition and Growth37
- Ch. 7 - Microbial Genetics51
- Ch. 8 - Recombinant DNA Technology21
- Ch. 9 - Controlling Microbial Growth in the Environment36
- Ch. 10 - Controlling Microbial Growth in the Body: Antimicrobial Drugs21
- Ch. 11 - Characterizing and Classifying Prokaryotes29
- Ch. 12 - Characterizing and Classifying Eukaryotes34
- Ch. 13 - Characterizing and Classifying Viruses, Viroids, and Prions23
- Ch. 14 - Infection, Infectious Diseases, and Epidemiology35
- Ch. 15 - Innate Immunity34
- Ch. 16 - Adaptive Immunity21
- Ch. 17 - Immunization and Immune Testing29
- Ch. 18 - Immune Disorders22
- Ch. 19 - Pathogenic Gram-Positive Bacteria25
- Ch. 20 - Pathogenic Gram-Negative Cocci and Bacilli28
- Ch. 21 - Rickettsias, Chlamydias, Spirochetes, and Vibrios25
- Ch. 22 - Pathogenic Fungi47
- Ch. 23 - Parasitic Protozoa, Helminths, and Arthropod Vectors44
- Ch. 24 - Pathogenic DNA Viruses23
- Ch. 25 - Pathogenic RNA Viruses30
- Ch. 26 - Applied and Industrial Microbiology29
- Ch. 27 - Microbial Ecology and Microbiomes22
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302Not the one you use?Change textbook
Chapter 18, Problem 3
Hemolytic disease of the newborn is caused by antibodies against which major blood group antigen?
a. MHC protein
b. MN antigen
c. ABO antigen
d. Rhesus antigen
e. Type II protein
Verified step by step guidance1
Understand that Hemolytic Disease of the Newborn (HDN) occurs when maternal antibodies target fetal red blood cell antigens, leading to hemolysis in the fetus or newborn.
Recall that the most common and clinically significant cause of HDN involves antibodies against the Rhesus (Rh) blood group system, specifically the D antigen.
Recognize that while ABO incompatibility can cause mild HDN, the classic and severe form is due to Rh incompatibility.
Eliminate options that are unrelated to red blood cell antigens involved in HDN, such as MHC proteins (immune system molecules), MN antigens (less commonly involved), and type II proteins (not relevant here).
Conclude that the major blood group antigen responsible for classic hemolytic disease of the newborn is the rhesus antigen.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Hemolytic Disease of the Newborn (HDN)
HDN is a condition where maternal antibodies attack fetal red blood cells, causing their destruction. This usually occurs when the mother is sensitized to fetal blood group antigens that she lacks, leading to immune-mediated hemolysis in the fetus or newborn.
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Rhesus (Rh) Blood Group System
The Rh blood group system includes several antigens, with the D antigen being the most significant. If an Rh-negative mother carries an Rh-positive fetus, she can develop antibodies against the Rh D antigen, which can cross the placenta and cause HDN.
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ABO Blood Group Antigens and Other Blood Group Systems
ABO antigens are common blood group markers but usually cause milder HDN. Other antigens like MN or MHC proteins are less commonly involved in HDN. Understanding the difference helps identify the primary cause of severe HDN cases.
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