Multiple Choice
Which of the following statements about the tuberculin skin test is true?
27. Immunological Disorders
Type IV Hypersensitivities
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Red, raised, and hardened skin patches in association with tuberculin injections are called indurations. Which cells are responsible for triggering the immune response to the tuberculin which results in indurations?
A
Sensitized B cells.
B
Sensitized T cells.
C
Sensitized plasma cells.
D
Anti-tuberculin antibodies.
Verified step by step guidance1
Understand that the tuberculin skin test (Mantoux test) is a type of delayed-type hypersensitivity reaction, which is a cell-mediated immune response rather than an antibody-mediated one.
Recognize that the induration (red, raised, hardened skin patch) results from the activation of immune cells at the site of the tuberculin injection.
Identify that sensitized T cells, specifically memory T helper cells (CD4+), recognize the tuberculin antigen presented by antigen-presenting cells in the skin.
Know that these sensitized T cells release cytokines that recruit and activate macrophages and other immune cells, leading to inflammation and the characteristic induration.
Conclude that sensitized T cells are responsible for triggering the immune response causing the induration, rather than B cells, plasma cells, or antibodies.
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