Textbook Question
Given that the indicated pKa values correspond to the acid dissociation reactions shown, calculate the ratio of acid to conjugate base for the reactions shown.
(a)
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3. Acids and Bases
Equilibrium Constant
6:19 minutesProblem 76b
Textbook Question
At what pH does 80% of the acid exist in its acidic form?
Verified step by step guidance1
Identify the relationship between the acidic form (HA) and its conjugate base (A⁻) using the Henderson-Hasselbalch equation: \( \text{pH} = \text{pKa} + \log \left( \frac{[A^-]}{[HA]} \right) \).
Determine the ratio of \([A^-]\) to \([HA]\) based on the problem statement. If 80% of the acid exists in its acidic form (HA), then \([HA] = 0.8\) and \([A^-] = 0.2\). The ratio \( \frac{[A^-]}{[HA]} \) is \( \frac{0.2}{0.8} = 0.25 \).
Substitute the ratio \( \frac{[A^-]}{[HA]} = 0.25 \) into the Henderson-Hasselbalch equation: \( \text{pH} = \text{pKa} + \log(0.25) \).
Simplify \( \log(0.25) \) using logarithmic properties: \( \log(0.25) = \log(1/4) = \log(1) - \log(4) = 0 - \log(4) = -\log(4) \).
Combine the simplified logarithmic term with the \( \text{pKa} \) to express the pH: \( \text{pH} = \text{pKa} - \log(4) \). This is the pH at which 80% of the acid exists in its acidic form.
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Video duration:
6mKey Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Acid-Base Equilibrium
Acid-base equilibrium refers to the balance between the concentrations of an acid and its conjugate base in a solution. This equilibrium is influenced by the pH of the solution, which determines the degree of ionization of the acid. Understanding this concept is crucial for determining the proportions of acidic and basic forms of a substance at a given pH.
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Henderson-Hasselbalch Equation
The Henderson-Hasselbalch equation is a mathematical formula that relates the pH of a solution to the pKa of an acid and the ratio of the concentrations of its deprotonated (base) and protonated (acid) forms. It is expressed as pH = pKa + log([A-]/[HA]). This equation is essential for calculating the pH at which a specific percentage of an acid exists in its acidic form.
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Percent Ionization
Percent ionization is a measure of the extent to which an acid dissociates into its ions in solution. It is calculated as the ratio of the concentration of ionized acid to the initial concentration of the acid, multiplied by 100. Knowing the percent ionization helps in understanding how much of the acid exists in its acidic form versus its ionized form at a specific pH.
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