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Multiple Choice
Which of the following syndromes is caused by a chromosomal translocation?
A
Chronic myelogenous leukemia (CML)
B
Klinefelter syndrome
C
Down syndrome
D
Turner syndrome
Verified step by step guidance
1
Understand the concept of chromosomal translocation: It is a genetic anomaly where a segment of one chromosome is transferred to another chromosome. This can lead to various genetic disorders or syndromes.
Identify the syndromes listed in the problem: Chronic myelogenous leukemia (CML), Klinefelter syndrome, Down syndrome, and Turner syndrome.
Review the genetic basis of each syndrome: CML is known to be caused by a specific chromosomal translocation, known as the Philadelphia chromosome, which involves a translocation between chromosome 9 and chromosome 22.
Compare the genetic causes of the other syndromes: Klinefelter syndrome is caused by an extra X chromosome (XXY), Down syndrome is caused by an extra chromosome 21 (trisomy 21), and Turner syndrome is caused by a missing or incomplete X chromosome (monosomy X). None of these are caused by translocations.
Conclude that Chronic myelogenous leukemia (CML) is the syndrome caused by a chromosomal translocation, specifically the translocation between chromosomes 9 and 22.