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Multiple Choice
The blood-brain barrier (BBB) is most permeable to which of the following?
A
Bacteria
B
Red blood cells
C
Proteins
D
Glucose
Verified step by step guidance
1
Understand the function of the blood-brain barrier (BBB): The BBB is a selective permeability barrier that protects the brain from potentially harmful substances in the bloodstream while allowing essential nutrients to pass through.
Identify the types of substances that can pass through the BBB: The BBB is most permeable to small, non-polar molecules and certain essential nutrients, such as glucose, which is crucial for brain function.
Consider the characteristics of each option: Bacteria, red blood cells, and proteins are generally large and polar, making them less likely to pass through the BBB compared to small, non-polar molecules like glucose.
Recognize the importance of glucose for brain function: Glucose is a primary energy source for the brain, and the BBB has specific transport mechanisms to facilitate its passage.
Conclude that glucose is the most permeable substance through the BBB among the given options, due to its small size and essential role in brain metabolism.