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Multiple Choice
Which of the following is true regarding the extrinsic pathway of blood clotting?
A
It is slower than the intrinsic pathway.
B
It requires the activation of factor XII.
C
It is initiated by tissue factor released from damaged tissues.
D
It does not involve calcium ions.
Verified step by step guidance
1
Understand the context: Blood clotting involves a series of complex processes that prevent excessive bleeding when a blood vessel is injured. There are two main pathways: intrinsic and extrinsic.
Identify the extrinsic pathway: The extrinsic pathway is initiated by external trauma that causes blood to escape from the vascular system. It is triggered by tissue factor (TF), also known as factor III, which is released by damaged tissues.
Compare the speed: The extrinsic pathway is generally faster than the intrinsic pathway because it involves fewer steps and is directly activated by tissue factor.
Factor XII involvement: Factor XII is part of the intrinsic pathway, not the extrinsic pathway. The extrinsic pathway does not require the activation of factor XII.
Role of calcium ions: Calcium ions are essential for both intrinsic and extrinsic pathways. They act as cofactors in various steps of the clotting process, including the activation of certain clotting factors.