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Multiple Choice
The blood-brain barrier is effective against which of the following?
A
Most bacteria and toxins
B
Glucose
C
Oxygen and carbon dioxide
D
Lipid-soluble substances
Verified step by step guidance
1
Step 1: Understand the concept of the blood-brain barrier (BBB). The BBB is a selective permeability barrier formed by endothelial cells in the brain's capillaries. It protects the brain by preventing harmful substances, such as bacteria and toxins, from entering the brain tissue while allowing essential nutrients and gases to pass through.
Step 2: Analyze the substances listed in the problem. The options include: 'Most bacteria and toxins,' 'Glucose,' 'Oxygen and carbon dioxide,' and 'Lipid-soluble substances.' Each of these interacts differently with the BBB based on its properties.
Step 3: Recall the mechanisms of transport across the BBB. The BBB allows small, lipid-soluble substances to diffuse freely, while larger or water-soluble molecules require specific transport mechanisms. Essential molecules like glucose are transported via facilitated diffusion, and gases like oxygen and carbon dioxide pass through by simple diffusion.
Step 4: Evaluate the effectiveness of the BBB against harmful substances. The BBB is highly effective at blocking most bacteria and toxins due to its tight junctions and selective transport mechanisms. However, lipid-soluble substances can bypass the barrier, which is why some drugs and alcohol can affect brain function.
Step 5: Conclude that the BBB is effective against 'Most bacteria and toxins,' as these are harmful substances that the barrier is specifically designed to block, while allowing essential molecules like glucose, oxygen, carbon dioxide, and lipid-soluble substances to pass through.