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Multiple Choice
Which cellular mediator is primarily involved in the development of Type I hypersensitivity reactions?
A
Macrophages
B
Mast cells
C
B cells
D
Neutrophils
Verified step by step guidance
1
Understand the context of Type I hypersensitivity reactions, which are also known as immediate allergic reactions. These reactions occur when the immune system responds excessively to a harmless substance, such as pollen or pet dander.
Recognize that Type I hypersensitivity is mediated by IgE antibodies. These antibodies bind to specific receptors on certain immune cells, leading to the release of inflammatory mediators.
Identify the key immune cells involved in Type I hypersensitivity. Mast cells are the primary cells that play a crucial role in these reactions. They are found in tissues throughout the body and contain granules rich in histamine and other chemicals.
Learn how mast cells contribute to the hypersensitivity reaction. When IgE antibodies on the surface of mast cells bind to an allergen, it triggers the mast cells to degranulate, releasing histamine and other substances that cause symptoms like swelling, redness, and itching.
Differentiate mast cells from other immune cells listed in the options, such as macrophages, B cells, and neutrophils. While these cells have important roles in the immune system, they are not primarily involved in Type I hypersensitivity reactions.