Table of contents

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1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

16. The Endocrine System

Intracellular Receptors and Direct Gene Action

Anatomy & Physiology

16. The Endocrine System

Intracellular Receptors and Direct Gene Action

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Multiple Choice

What is the mechanism of action of lipid-soluble hormones?

They are transported in the blood bound to carrier proteins and act on cell surface receptors.

They bind to cell surface receptors and activate second messenger systems.

They are stored in vesicles and released in response to a stimulus.

They bind to intracellular receptors and directly influence gene expression.

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Verified step by step guidance

Understand that lipid-soluble hormones, such as steroid hormones, can easily pass through the lipid bilayer of cell membranes due to their solubility in lipids.

Recognize that once inside the cell, these hormones bind to specific intracellular receptors located in the cytoplasm or nucleus.

Note that the hormone-receptor complex then translocates to the nucleus if it hasn't already bound there.

In the nucleus, the hormone-receptor complex binds to specific DNA sequences, known as hormone response elements, which are located near the genes they regulate.

This binding directly influences gene expression by either promoting or inhibiting the transcription of specific genes, leading to changes in protein synthesis and cellular function.