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Multiple Choice
What protein is phosphorylated first during receptor tyrosine kinase (RTK) activation?
A
G-protein
B
Adenylate cyclase
C
Protein kinase A
D
The receptor itself
Verified step by step guidance
1
Understand the role of receptor tyrosine kinases (RTKs) in cell signaling. RTKs are a type of cell surface receptor that, upon binding with a ligand, undergo autophosphorylation, which is the addition of phosphate groups to the receptor itself.
Recognize that the phosphorylation process is crucial for the activation of RTKs. This phosphorylation occurs on specific tyrosine residues within the receptor's intracellular domain.
Identify that the first protein to be phosphorylated during RTK activation is the receptor itself. This autophosphorylation is a key step that initiates downstream signaling pathways.
Consider the downstream effects of RTK activation. Once the receptor is phosphorylated, it can interact with various signaling proteins, leading to a cascade of cellular responses.
Reflect on the importance of RTK autophosphorylation in cellular communication and its implications in processes such as growth, differentiation, and metabolism.