Solutions A and B are separated by a selectively permeable barrier. Over time, the level of fluid on side A increases. Which solution initially had the higher concentration of solute?
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2. Cell Chemistry & Cell Components
Introduction to Membrane Transport
Problem 4
Textbook Question
____ ion concentration is high in extracellular fluids, and____ion concentration is high in the cytoplasm.
(a) Calcium; magnesium
(b) Chloride; sodium
(c) Potassium; sodium
(d) Sodium; potassium

1
Step 1: Understand the context of the problem. The question is asking about the relative concentrations of specific ions in extracellular fluid versus the cytoplasm. This is a fundamental concept in cell physiology, particularly in understanding ion gradients and membrane potential.
Step 2: Recall the key principle of ion distribution in cells. Sodium (Na⁺) ions are typically found in higher concentrations in extracellular fluid, while potassium (K⁺) ions are found in higher concentrations inside the cytoplasm. This distribution is maintained by the sodium-potassium pump (Na⁺/K⁺ ATPase).
Step 3: Eliminate incorrect options based on your knowledge of ion distribution. For example, calcium (Ca²⁺) and magnesium (Mg²⁺) are not the primary ions involved in this specific gradient, so option (a) can be ruled out. Similarly, chloride (Cl⁻) and sodium (Na⁺) are not paired correctly for this context, so option (b) can be eliminated.
Step 4: Focus on the correct pairing of ions. Sodium (Na⁺) is high in extracellular fluid, and potassium (K⁺) is high in the cytoplasm. This matches the description in option (d).
Step 5: Review the physiological significance of this ion distribution. The sodium-potassium pump actively transports Na⁺ out of the cell and K⁺ into the cell, which is crucial for maintaining osmotic balance, electrical excitability, and overall cell function.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Extracellular and Intracellular Ion Concentrations
Extracellular fluids are the body fluids located outside of cells, where certain ions, such as sodium (Na+), are typically found in higher concentrations. In contrast, intracellular fluids, which are found within cells, often have higher concentrations of potassium (K+). Understanding these distributions is crucial for grasping cellular functions and signaling.
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Intracellular Receptors and Direct Gene Action Example 1
Sodium-Potassium Pump
The sodium-potassium pump is a vital membrane protein that actively transports sodium ions out of the cell and potassium ions into the cell. This process is essential for maintaining the electrochemical gradient across the cell membrane, which is critical for various cellular processes, including nerve impulse transmission and muscle contraction.
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The Sodium Potassium Pump
Ion Roles in Cellular Function
Ions play significant roles in various cellular functions, including maintaining osmotic balance, generating action potentials in neurons, and facilitating muscle contractions. The specific concentrations of ions like sodium and potassium are crucial for these processes, as they influence the cell's resting membrane potential and overall excitability.
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Ions - Sodium and Potassium Example 3
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