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Multiple Choice
Which enzyme is used both in gluconeogenesis and glycogenolysis?
A
Pyruvate kinase
B
Hexokinase
C
Glucose-6-phosphatase
D
Phosphofructokinase
Verified step by step guidance
1
Understand the processes: Gluconeogenesis is the synthesis of glucose from non-carbohydrate sources, while glycogenolysis is the breakdown of glycogen into glucose.
Identify the role of enzymes: Enzymes are biological catalysts that speed up chemical reactions. Each step in metabolic pathways like gluconeogenesis and glycogenolysis is catalyzed by specific enzymes.
Focus on glucose-6-phosphatase: This enzyme is crucial in both gluconeogenesis and glycogenolysis. In gluconeogenesis, it catalyzes the final step, converting glucose-6-phosphate into free glucose. In glycogenolysis, it performs the same conversion, releasing glucose into the bloodstream.
Differentiate from other enzymes: Pyruvate kinase and hexokinase are involved in glycolysis, not gluconeogenesis or glycogenolysis. Phosphofructokinase is also a glycolytic enzyme, emphasizing the specificity of glucose-6-phosphatase in the mentioned pathways.
Conclude the enzyme's importance: Glucose-6-phosphatase is essential for maintaining blood glucose levels, especially during fasting, by facilitating the release of glucose from the liver.