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Multiple Choice
Which of the following adrenergic receptors increases cAMP levels?
A
Beta-1 adrenergic receptor
B
Alpha-2 adrenergic receptor
C
Beta-2 adrenergic receptor
D
Alpha-1 adrenergic receptor
Verified step by step guidance
1
Understand the role of adrenergic receptors: Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, like adrenaline and noradrenaline. They are divided into alpha and beta receptors, each with subtypes that have different effects on the body.
Identify the mechanism of action: Beta adrenergic receptors generally work through the activation of adenylate cyclase, which increases the levels of cyclic AMP (cAMP) in the cell. This is a key signaling molecule that can lead to various physiological responses.
Differentiate between receptor subtypes: Beta-1 and Beta-2 adrenergic receptors both increase cAMP levels. Beta-1 receptors are primarily found in the heart and increase heart rate and force of contraction. Beta-2 receptors are found in various tissues, including the lungs, and cause smooth muscle relaxation.
Consider the effects of alpha adrenergic receptors: Alpha-1 adrenergic receptors typically work through a different pathway involving phospholipase C, leading to increased intracellular calcium levels. Alpha-2 receptors generally inhibit adenylate cyclase, reducing cAMP levels.
Conclude which receptor increases cAMP: Based on the mechanisms, Beta-1 and Beta-2 adrenergic receptors are responsible for increasing cAMP levels. Therefore, the correct answer is Beta-2 adrenergic receptor, as it is one of the options provided.