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Multiple Choice
Which portion of an antibody binds to an antigen?
A
Fc region
B
Variable region
C
Hinge region
D
Constant region
Verified step by step guidance
1
Understand the structure of an antibody: Antibodies, also known as immunoglobulins, are Y-shaped proteins that play a crucial role in the immune response by identifying and neutralizing foreign objects like bacteria and viruses.
Identify the regions of an antibody: An antibody consists of two main regions - the constant region (Fc region) and the variable region. The constant region is responsible for effector functions, while the variable region is involved in antigen binding.
Focus on the variable region: The variable region is located at the tips of the 'Y' shape of the antibody. It is called 'variable' because it varies greatly between different antibodies, allowing them to bind specifically to a wide variety of antigens.
Understand antigen binding: The variable region contains the antigen-binding sites, which are specific to particular antigens. This specificity is due to the unique amino acid sequences in the variable region that form a specific three-dimensional structure complementary to the antigen.
Conclude that the variable region is responsible for binding to the antigen: The antigen-binding sites within the variable region interact with the antigen's epitopes, allowing the antibody to attach to the antigen and mark it for destruction or neutralization by the immune system.