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Multiple Choice
A patient excretes a large volume of very dilute urine on a continuing basis. This may be due to:
A
decreased glomerular filtration rate
B
absence of antidiuretic hormone (ADH)
C
increased reabsorption of water in the collecting ducts
D
oversecretion of aldosterone
Verified step by step guidance
1
Understand the role of antidiuretic hormone (ADH): ADH is responsible for increasing water reabsorption in the kidneys by making the collecting ducts more permeable to water. Its absence leads to the excretion of large volumes of dilute urine.
Analyze the options provided: Evaluate each option based on its physiological impact on urine production. For example, decreased glomerular filtration rate would reduce urine volume, not increase it.
Focus on the absence of ADH: Without ADH, the collecting ducts in the kidneys cannot reabsorb water effectively, leading to dilute urine. This is a key physiological mechanism to consider.
Rule out other options: Increased reabsorption of water in the collecting ducts would result in concentrated urine, not dilute urine. Oversecretion of aldosterone primarily affects sodium reabsorption, not water reabsorption directly.
Conclude that the absence of ADH is the most plausible explanation for the patient's symptoms, as it directly correlates with the production of large volumes of dilute urine.