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Multiple Choice
What does the G2 checkpoint in the cell cycle primarily check for?
A
Proper alignment of chromosomes during metaphase
B
Sufficient cell size and nutrient availability
C
Attachment of spindle fibers to kinetochores
D
Completion of DNA replication and DNA damage repair
Verified step by step guidance
1
Understand the context of the G2 checkpoint: The G2 checkpoint is a critical control mechanism in the cell cycle that ensures cells do not initiate mitosis before they are ready.
Identify the primary function of the G2 checkpoint: The G2 checkpoint primarily checks for the completion of DNA replication and the repair of any DNA damage that may have occurred during the S phase.
Differentiate between the functions of various checkpoints: The G1 checkpoint checks for cell size, nutrients, and DNA damage before DNA replication. The metaphase checkpoint (also known as the spindle checkpoint) ensures proper alignment of chromosomes and attachment of spindle fibers to kinetochores.
Relate the G2 checkpoint to the overall cell cycle: The G2 checkpoint occurs after the S phase and before the M phase (mitosis), ensuring that the cell is fully prepared to enter mitosis with intact and accurately replicated DNA.
Summarize the importance of the G2 checkpoint: By ensuring DNA replication is complete and any damage is repaired, the G2 checkpoint helps maintain genomic stability and prevents the propagation of errors to daughter cells.