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Multiple Choice
What is the effect of nitric oxide on systemic arterioles?
A
Vasoconstriction
B
Increased heart rate
C
Vasodilation
D
No effect
Verified step by step guidance
1
Understand the role of nitric oxide (NO) in the cardiovascular system: Nitric oxide is a signaling molecule produced by endothelial cells lining blood vessels. It plays a critical role in regulating vascular tone and blood flow.
Learn the mechanism of action of nitric oxide: NO activates the enzyme guanylate cyclase in smooth muscle cells of blood vessels. This leads to an increase in cyclic guanosine monophosphate (cGMP) levels, which causes relaxation of the smooth muscle.
Connect the relaxation of smooth muscle to vasodilation: When the smooth muscle in systemic arterioles relaxes, the diameter of the blood vessels increases, leading to vasodilation. This reduces vascular resistance and improves blood flow.
Rule out other options: Vasoconstriction is the opposite effect and occurs when smooth muscle contracts, which nitric oxide does not promote. Increased heart rate is unrelated to the direct action of nitric oxide on arterioles. 'No effect' is incorrect because nitric oxide has a significant impact on vascular tone.
Conclude that the correct answer is vasodilation: Nitric oxide causes systemic arterioles to dilate, improving blood flow and reducing blood pressure.