Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

6. Bones & Skeletal Tissue

Gross Anatomy of Bone: Compact and Spongy Bone

Anatomy & Physiology

6. Bones & Skeletal Tissue

Gross Anatomy of Bone: Compact and Spongy Bone

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Problem 12

Textbook Question

Correctly order the following steps of bone growth in length by placing a 1 by the first step, a 2 by the second step, and so on.
Calcified cartilage is replaced with bone in the zone of ossification.
Chondrocytes in the zone of proliferation divide by mitosis.
Chondrocytes enter the zone of calcification and die as their matrix calcifies.
Chondrocytes enlarge and cease dividing.

Verified step by step guidance

Understand that the process of bone growth in length occurs at the epiphyseal plate (growth plate) and involves several zones: the zone of proliferation, the zone of hypertrophy, the zone of calcification, and the zone of ossification.

Identify the first step: In the zone of proliferation, chondrocytes divide by mitosis to produce new cartilage, which pushes the epiphysis away from the diaphysis, lengthening the bone.

Identify the second step: In the zone of hypertrophy, chondrocytes enlarge (hypertrophy) and cease dividing, preparing for the next stage of calcification.

Identify the third step: In the zone of calcification, the matrix surrounding the chondrocytes calcifies, and the chondrocytes die due to lack of nutrients.

Identify the fourth step: In the zone of ossification, the calcified cartilage is replaced with bone tissue by osteoblasts, completing the process of bone lengthening.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Zones of Growth in Long Bones

Long bone growth occurs in specific zones within the epiphyseal plate, which include the zone of proliferation, zone of hypertrophy, zone of calcification, and zone of ossification. Each zone has distinct functions, such as chondrocyte division and maturation, which contribute to the overall lengthening of the bone.

Chondrocyte Function

Chondrocytes are specialized cells found in cartilage that play a crucial role in bone growth. They undergo processes such as mitosis in the zone of proliferation, enlargement in the zone of hypertrophy, and eventual death in the zone of calcification, which is essential for the transition from cartilage to bone.

Ossification Process

Ossification is the process by which cartilage is transformed into bone. In the zone of ossification, calcified cartilage is replaced by bone tissue, allowing for the structural integrity and strength of the growing bone. This process is vital for the proper development and maintenance of the skeletal system.

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Related Practice

Multiple Choice

Osteocytes maintain contact with the blood vessels of the central canal through __________.

The lacunae of bone contain __________.

Spongy bone contains all of the following EXCEPT __________.

If a person's spongy bone were all replaced by compact bone, how may that affect the function of their bones and skeleton?

Yolanda is asked to review a bone slide that her professor has set up under the microscope. She sees concentric layers surrounding a central cavity. Is this bone section taken from the diaphysis or the epiphyseal plate of the specimen?

What is yellow marrow? How do spongy and compact bone look different?

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Textbook Question

If spongy bone has no osteons, how do nutrients reach the osteocytes?

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Multiple Choice