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Multiple Choice
What initiates the extrinsic mechanism of coagulation?
A
Platelet activation
B
Calcium ion release
C
Tissue factor released by damaged tissues
D
Conversion of fibrinogen to fibrin
Verified step by step guidance
1
Understand the coagulation process: Coagulation is the process by which blood forms clots. It involves a series of steps that lead to the conversion of fibrinogen, a soluble plasma protein, into fibrin, an insoluble protein that forms the meshwork of a clot.
Differentiate between intrinsic and extrinsic pathways: The coagulation cascade can be initiated by two pathways - intrinsic and extrinsic. The intrinsic pathway is activated by trauma inside the vascular system, while the extrinsic pathway is activated by external trauma that causes blood to escape from the vascular system.
Identify the role of tissue factor: The extrinsic pathway is initiated by the release of tissue factor (also known as factor III or thromboplastin) from damaged tissues. Tissue factor is a protein that is exposed when tissues are injured, and it interacts with factor VII in the blood to start the coagulation cascade.
Consider the role of calcium ions: Calcium ions are crucial for various steps in the coagulation cascade, including the activation of certain clotting factors. However, they do not initiate the extrinsic pathway.
Recognize the conversion of fibrinogen to fibrin: This conversion is a key step in the formation of a stable clot, but it occurs later in the coagulation process, after the cascade has been initiated by tissue factor.