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Multiple Choice
Which of the following is correct about protein folding?
A
Protein folding is primarily determined by the sequence of nucleotides in DNA.
B
Protein folding is a reversible process that occurs in the cytoplasm only.
C
Protein folding is a spontaneous process driven by the hydrophobic effect.
D
Protein folding requires the input of energy in the form of ATP.
Verified step by step guidance
1
Understand that protein folding is the process by which a protein structure assumes its functional shape or conformation.
Recognize that the primary structure of a protein, which is its sequence of amino acids, is determined by the sequence of nucleotides in DNA. However, the folding itself is not directly determined by DNA but by the interactions between amino acids.
Acknowledge that protein folding is a spontaneous process, meaning it occurs naturally without the need for external energy input. This is primarily driven by the hydrophobic effect, where non-polar amino acid side chains tend to avoid water and aggregate in the interior of the protein.
Note that while protein folding can be reversible under certain conditions, it is not limited to occurring only in the cytoplasm. It can also occur in other cellular compartments, such as the endoplasmic reticulum.
Understand that while ATP is not required for the spontaneous folding of proteins, molecular chaperones, which assist in the folding process, may require ATP to function.