After falling into an abandoned stone quarry filled with water and nearly drowning, a young boy is rescued. In assessing his condition, rescuers find that his body fluids have high PCO₂ and lactate levels and low PO₂ levels. Identify the underlying problem and recommend the necessary treatment to restore homeostatic conditions.
Table of contents
- 1. Introduction to Anatomy & Physiology5h 43m
- What is Anatomy & Physiology?22m
- Levels of Organization13m
- Variation in Anatomy & Physiology12m
- Introduction to Organ Systems27m
- Homeostasis10m
- Feedback Loops11m
- Feedback Loops: Negative Feedback19m
- Feedback Loops: Positive Feedback11m
- Anatomical Position7m
- Introduction to Directional Terms3m
- Directional Terms: Up and Down9m
- Directional Terms: Front and Back6m
- Directional Terms: Body Sides12m
- Directional Terms: Limbs6m
- Directional Terms: Depth Within the Body4m
- Introduction to Anatomical Terms for Body Regions3m
- Anatomical Terms for the Head and Neck8m
- Anatomical Terms for the Front of the Trunk8m
- Anatomical Terms for the Back9m
- Anatomical Terms for the Arm and Hand9m
- Anatomical Terms for the Leg and Foot15m
- Review- Using Anatomical Terms and Directions12m
- Abdominopelvic Quadrants and Regions19m
- Anatomical Planes & Sections17m
- Organization of the Body: Body Cavities13m
- Organization of the Body: Serous Membranes14m
- Organization of the Body: Serous Membrane Locations8m
- Organization of the Body: Thoracic Cavity8m
- Organization of the Body: Abdominopelvic Cavity12m
- 2. Cell Chemistry & Cell Components12h 36m
- Atoms- Smallest Unit of Matter57m
- Isotopes39m
- Introduction to Chemical Bonding19m
- Covalent Bonds40m
- Noncovalent Bonds5m
- Ionic Bonding37m
- Hydrogen Bonding19m
- Introduction to Water7m
- Properties of Water- Cohesion and Adhesion7m
- Properties of Water- Density8m
- Properties of Water- Thermal14m
- Properties of Water- The Universal Solvent17m
- Acids and Bases12m
- pH Scale21m
- Carbon8m
- Functional Groups9m
- Introduction to Biomolecules2m
- Monomers & Polymers11m
- Carbohydrates23m
- Proteins25m
- Nucleic Acids34m
- Lipids28m
- Microscopes11m
- Prokaryotic & Eukaryotic Cells26m
- Introduction to Eukaryotic Organelles14m
- Endomembrane System: Protein Secretion30m
- Endomembrane System: Digestive Organelles14m
- Mitochondria & Chloroplasts21m
- Endosymbiotic Theory10m
- Introduction to the Cytoskeleton11m
- Cell Junctions8m
- Biological Membranes11m
- Types of Membrane Proteins8m
- Concentration Gradients and Diffusion9m
- Introduction to Membrane Transport16m
- Passive vs. Active Transport14m
- Osmosis30m
- Simple and Facilitated Diffusion17m
- Active Transport30m
- Endocytosis and Exocytosis15m
- 3. Energy & Cell Processes10h 6m
- Introduction to Energy15m
- Laws of Thermodynamics15m
- Chemical Reactions9m
- ATP20m
- Enzymes14m
- Enzyme Activation Energy9m
- Enzyme Binding Factors9m
- Enzyme Inhibition10m
- Introduction to Metabolism8m
- Redox Reactions15m
- Introduction to Cellular Respiration22m
- Types of Phosphorylation14m
- Glycolysis19m
- Pyruvate Oxidation8m
- Krebs Cycle16m
- Electron Transport Chain10m
- Chemiosmosis7m
- Review of Aerobic Cellular Respiration19m
- Fermentation & Anaerobic Respiration23m
- Introduction to Cell Division22m
- Organization of DNA in the Cell17m
- Introduction to the Cell Cycle7m
- Interphase18m
- Phases of Mitosis48m
- Cytokinesis16m
- Cell Cycle Regulation18m
- Review of the Cell Cycle7m
- Cancer13m
- Introduction to DNA Replication22m
- DNA Repair8m
- Central Dogma7m
- Introduction to Transcription20m
- Steps of Transcription19m
- Genetic Code25m
- Introduction to Translation30m
- Steps of Translation23m
- Post-Translational Modification6m
- 4. Tissues & Histology10h 3m
- Introduction to Tissues & Histology16m
- Introduction to Epithelial Tissue24m
- Characteristics of Epithelial Tissue37m
- Structural Naming of Epithelial Tissue19m
- Simple Epithelial Tissues1h 2m
- Stratified Epithelial Tissues55m
- Identifying Types of Epithelial Tissue32m
- Glandular Epithelial Tissue26m
- Introduction to Connective Tissue36m
- Classes of Connective Tissue8m
- Introduction to Connective Tissue Proper40m
- Connective Tissue Proper: Loose Connective Tissue56m
- Connective Tissue Proper: Dense Connective Tissue49m
- Specialized Connective Tissue: Cartilage44m
- Specialized Connective Tissue: Bone12m
- Specialized Connective Tissue: Blood9m
- Introduction to Muscle Tissue7m
- Types of Muscle Tissue45m
- Introduction to Nervous Tissue8m
- Nervous Tissue: The Neuron8m
- 5. Integumentary System2h 20m
- 6. Bones & Skeletal Tissue2h 16m
- An Introduction to Bone and Skeletal Tissue18m
- Gross Anatomy of Bone: Compact and Spongy Bone7m
- Gross Anatomy of Bone: Periosteum and Endosteum11m
- Gross Anatomy of Bone: Bone Marrow8m
- Gross Anatomy of Bone: Short, Flat, and Irregular Bones5m
- Gross Anatomy of Bones - Structure of a Long Bone23m
- Microscopic Anatomy of Bones - Bone Matrix9m
- Microscopic Anatomy of Bones - Bone Cells25m
- Microscopic Anatomy of Bones - The Osteon17m
- Microscopic Anatomy of Bones - Trabeculae9m
- 7. The Skeletal System2h 35m
- 8. Joints2h 17m
- 9. Muscle Tissue2h 33m
- 10. Muscles1h 11m
- 11. Nervous Tissue and Nervous System1h 35m
- 12. The Central Nervous System1h 6m
- 13. The Peripheral Nervous System1h 26m
- Introduction to the Peripheral Nervous System5m
- Organization of Sensory Pathways16m
- Introduction to Sensory Receptors5m
- Sensory Receptor Classification by Modality6m
- Sensory Receptor Classification by Location8m
- Proprioceptors7m
- Adaptation of Sensory Receptors8m
- Introduction to Reflex Arcs13m
- Reflex Arcs15m
- 14. The Autonomic Nervous System1h 38m
- 15. The Special Senses2h 41m
- 16. The Endocrine System2h 48m
- 17. The Blood3h 22m
- 18. The Heart3h 42m
- 19. The Blood Vessels3h 35m
- 20. The Lymphatic System3h 16m
- 21. The Immune System14h 37m
- Introduction to the Immune System10m
- Introduction to Innate Immunity17m
- Introduction to First-Line Defenses5m
- Physical Barriers in First-Line Defenses: Skin13m
- Physical Barriers in First-Line Defenses: Mucous Membrane9m
- First-Line Defenses: Chemical Barriers24m
- First-Line Defenses: Normal Microbiota7m
- Introduction to Cells of the Immune System15m
- Cells of the Immune System: Granulocytes28m
- Cells of the Immune System: Agranulocytes26m
- Introduction to Cell Communication5m
- Cell Communication: Surface Receptors & Adhesion Molecules16m
- Cell Communication: Cytokines27m
- Pattern Recognition Receptors (PRRs)48m
- Introduction to the Complement System24m
- Activation Pathways of the Complement System23m
- Effects of the Complement System23m
- Review of the Complement System13m
- Phagocytosis17m
- Introduction to Inflammation18m
- Steps of the Inflammatory Response28m
- Fever8m
- Interferon Response25m
- Review Map of Innate Immunity
- Introduction to Adaptive Immunity32m
- Antigens12m
- Introduction to T Lymphocytes38m
- Major Histocompatibility Complex Molecules20m
- Activation of T Lymphocytes21m
- Functions of T Lymphocytes25m
- Review of Cytotoxic vs Helper T Cells13m
- Introduction to B Lymphocytes27m
- Antibodies14m
- Classes of Antibodies35m
- Outcomes of Antibody Binding to Antigen15m
- T Dependent & T Independent Antigens21m
- Clonal Selection20m
- Antibody Class Switching17m
- Affinity Maturation14m
- Primary and Secondary Response of Adaptive Immunity21m
- Immune Tolerance28m
- Regulatory T Cells10m
- Natural Killer Cells16m
- Review of Adaptive Immunity25m
- 22. The Respiratory System3h 20m
- 23. The Digestive System2h 5m
- 24. Metabolism and Nutrition4h 0m
- Essential Amino Acids5m
- Lipid Vitamins19m
- Cellular Respiration: Redox Reactions15m
- Introduction to Cellular Respiration22m
- Cellular Respiration: Types of Phosphorylation14m
- Cellular Respiration: Glycolysis19m
- Cellular Respiration: Pyruvate Oxidation8m
- Cellular Respiration: Krebs Cycle16m
- Cellular Respiration: Electron Transport Chain14m
- Cellular Respiration: Chemiosmosis7m
- Review of Aerobic Cellular Respiration18m
- Fermentation & Anaerobic Respiration23m
- Gluconeogenesis16m
- Fatty Acid Oxidation20m
- Amino Acid Oxidation17m
- 25. The Urinary System2h 39m
- 26. Fluid and Electrolyte Balance, Acid Base Balance37m
- 27. The Reproductive System2h 5m
- 28. Human Development1h 21m
- 29. Heredity3h 32m
26. Fluid and Electrolyte Balance, Acid Base Balance
Acid-Base Balance
Problem 24
Textbook Question
The most recent advice from medical and nutritional experts is to monitor one’s intake of salt so that it does not exceed the amount needed to maintain a constant ECF volume. What effect does excessive salt ingestion have on blood pressure?

1
Understand the relationship between salt intake and extracellular fluid (ECF) volume: Excessive salt ingestion increases the concentration of sodium ions (Na⁺) in the extracellular fluid. Sodium is osmotically active, meaning it attracts water, leading to an increase in ECF volume.
Recognize the connection between ECF volume and blood pressure: An increase in ECF volume raises blood volume, which in turn increases venous return to the heart. This leads to an increase in cardiac output, as per the Frank-Starling mechanism.
Apply the concept of blood pressure regulation: Blood pressure is determined by cardiac output and peripheral resistance. An increase in cardiac output due to higher blood volume will elevate blood pressure.
Consider the role of the kidneys: The kidneys play a critical role in regulating blood pressure by excreting excess sodium and water. However, if salt intake consistently exceeds the kidneys' ability to excrete it, blood pressure may remain elevated over time.
Relate to potential health consequences: Chronic high blood pressure (hypertension) due to excessive salt intake can strain the cardiovascular system, increasing the risk of conditions such as heart disease, stroke, and kidney damage.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Extracellular Fluid (ECF) Volume
Extracellular fluid volume refers to the amount of fluid outside the cells in the body, which includes interstitial fluid and plasma. Maintaining a constant ECF volume is crucial for normal physiological functions, as it influences blood pressure and overall fluid balance. An increase in ECF volume can lead to hypertension, as the heart must work harder to pump the increased volume of blood.
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Sodium's Role in Blood Pressure Regulation
Sodium is a key electrolyte that helps regulate blood pressure by influencing fluid balance in the body. When sodium intake is high, it can cause the body to retain more water, leading to an increase in blood volume. This increased blood volume can elevate blood pressure, making it essential to monitor sodium intake to prevent hypertension and related cardiovascular issues.
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Hypertension
Hypertension, or high blood pressure, is a condition where the force of the blood against the artery walls is consistently too high. It can lead to serious health problems, including heart disease and stroke. Excessive salt intake is a significant risk factor for developing hypertension, as it contributes to increased blood volume and vascular resistance, necessitating lifestyle modifications to manage blood pressure effectively.
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