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Multiple Choice
Tissue culture experiments with PDGF demonstrate that without this substance, __________.
A
bacterial cells lose their resistance to antibiotics
B
cells divide in an uncontrolled fashion, confirming PDGF's role as a cell division inhibitor
C
animal cells are unable to attach to the substratum
D
the various kinases, such as MPF, are unable to bind to cyclin
E
fibroblasts fail to divide
Verified step by step guidance
1
Understand the role of PDGF (Platelet-Derived Growth Factor) in cell division. PDGF is a growth factor that regulates cell growth and division, particularly in fibroblasts, which are a type of animal cell.
Recognize that fibroblasts are connective tissue cells that play a crucial role in wound healing and tissue repair. They require specific signals to divide and proliferate.
Identify that PDGF acts as a signaling molecule that binds to receptors on the surface of fibroblasts, initiating a cascade of events that lead to cell division.
Consider the absence of PDGF in tissue culture experiments. Without PDGF, the signaling pathway necessary for fibroblast division is not activated, leading to a failure in cell division.
Conclude that the correct answer is that fibroblasts fail to divide without PDGF, highlighting its essential role in the regulation of cell division in these cells.