Skip to main content
Ch. 28 Pregnancy and Human Development
Marieb - Human Anatomy & Physiology 11th Edition
Marieb, Hoehn11th EditionHuman Anatomy & PhysiologyISBN: 9780136874034Not the one you use?Change textbook
Chapter 28, Problem 17

Why is it that only one sperm out of the hundreds (or thousands) available enters the oocyte?

Verified step by step guidance
1
Understand the process of fertilization, where many sperm cells compete to penetrate the oocyte (egg cell).
Recognize that the oocyte is surrounded by protective layers, including the zona pellucida, which only allows one sperm to bind and initiate penetration.
Learn about the acrosomal reaction, where the sperm releases enzymes to digest a path through the zona pellucida, but this reaction is triggered effectively by only one sperm at a time.
Explore the concept of the cortical reaction, which occurs immediately after one sperm fuses with the oocyte membrane, causing changes in the zona pellucida that prevent any additional sperm from entering (a process called polyspermy block).
Conclude that these mechanisms ensure that only one sperm fertilizes the oocyte, maintaining the correct number of chromosomes for normal embryonic development.

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Sperm Competition and Selection

Although many sperm reach the oocyte, only one fertilizes it due to competitive and selective mechanisms. The sperm must be the first to penetrate the protective layers of the oocyte, ensuring that only the most viable sperm achieves fertilization.
Recommended video:
6:43
Clonal Selection

Zona Pellucida and Acrosome Reaction

The zona pellucida is a glycoprotein layer surrounding the oocyte that sperm must penetrate. The acrosome reaction releases enzymes from the sperm head, allowing it to digest this layer and enter the oocyte, a process that only one sperm successfully completes.
Recommended video:
01:56
Chemical Reactions

Polyspermy Prevention Mechanisms

Once a sperm enters the oocyte, the oocyte triggers changes to prevent additional sperm from entering, such as the cortical reaction that hardens the zona pellucida. This ensures only one sperm fertilizes the egg, maintaining the correct chromosome number.
Recommended video:
3:02
Internal Regulation - The Myogenic Mechanism